From the MOTU Core Installer, you can choose Custom Install. Select the PCI-324 ASIO driver and it will be installed to the ASIO Drivers folder in your Cubase Folder. On a PC, when you run the installer you will have the option to install the ASIO Driver as well as the Wave Driver. On a PC, the ASIO driver is installed into the Windows > System Folder.

Open the PCI-324 Console. Set the Clock source to Internal (when working with analog). Pick a sample rate. Assign one bank to Analog. Enable all 8 inputs. Then assign the output source as "From Computer". If "Enable Routing" is unchecked you will not see the extra menus for inputs and outputs and we enable the inputs and outputs for you. For additional connections with digital devices you can refer to your 2408 manual as well as the Auto Setup Wizard for further instructions. For now, this basic configuration will get you going.

The following steps will help get you started in Cubase VST:

1. In the Options Menu > Audio Setup > System, you can choose PCI-324 as your ASIO driver. You can also assign the Clock Source and the Sample Rate in this window.
2. In the Panels Menu > VST Inputs, under Audio Inputs, you must also enable the PCI-324 Inputs that you will be using with Cubase. You will only have the option of selecting inputs that you have already enabled with the PCI-324 Console.
3. Under the Options menu you must also activate Multi-Record to record more than one input at a time in Cubase.
4. In the Mixing Window you can Command-Click on the input buttons to select any available input. Then you must assign the output of that channel to a Sub-group.
5. In the Master Mix window you can now assign your sub-groups to stereo output pairs on the 2408.