Any PC equipped with a Texas Instrument or Lucent based FireWire card should be compatible with our FireWire line. The chipset of the motherboard, e.g. Intel vs. AMD, is not particularly relevant to FireWire compatibility. That being said, a quality PC is recommended. A fast processor, lots of RAM, a fast hard drive, etc. are all necessary components of a good DAW. Consult the manufacturer of your software to determine what kind of PC they recommend for best results with their software, and also feel free to call MOTU for more guidance.