Due to the updated security architecture introduced since macOS 10.13 High Sierra, the system extensions for all newly-installed third-party software will automatically be blocked from running. If your MOTU interface is not showing up in Audio MIDI Setup, MOTU Audio Setup, MOTU Discovery, or your DAW on macOS 11 Big Sur, you might need to enable the driver in your System Preferences.

To enable the MOTU drivers, follow these steps:

1. Download and install the very latest installer for your MOTU interface.
2. After restarting, open System Preferences.
3. Select Security & Privacy.
4. In the General section, click the Allow button.

• The Allow button will disappear 30 minutes after installation. To display the Allow button, run the installer for the MOTU driver again.
• This behavior will only occur when installing a MOTU driver for the first time on macOS 11 Big Sur. If you have already installed the driver on an earlier version of macOS and upgraded to macOS 11 Big Sur, you should not need to enable the driver.
• This issue is not specific to MOTU. It is a general change introduced in macOS 10.13 High Sierra, and will affect any third-party (i.e. non-Apple) kernel extensions.